Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells
نویسندگان
چکیده
منابع مشابه
Expression and activity of Apaf1 and caspase-9 in granulosa cells during follicular atresia in pig ovaries.
Apoptosis in granulosa cells plays a crucial role in ovarian follicular atresia, but the intracellular regulating mechanism, especially the mitochondrion-dependent apoptosis signalling pathway, is still largely unknown. This study examined whether the mitochondrial pathway is associated with granulosa cell apoptosis during atresia in pig ovaries. Both mRNAs of caspase-9 and apoptotic protease-a...
متن کاملRegulation of cell death and cell survival gene expression during ovarian follicular development and atresia.
Mammalian ovarian follicular development and atresia is closely regulated by the cross talk of cell death and cell survival signals, which include endocrine hormones (gonadotropins) and intra-ovarian regulators (gonadal steroids, cytokines and growth factors). The fate of the follicle is dependent on a delicate balance in the expression and actions of factors promoting follicular cell prolifera...
متن کاملRegulation of Follicular Growth and Development in Sheep
This manuscript reviews the present knowledge related to folliculogenesis in sheep.Folliculogenesis starts with formation of primordial follicles before birth, present as a pool containing a certain number of follicles. By the attainment of puberty, a group of follicles from that pool starts to grow, a process known as primordial follicle activation or recruitment. The number of growing primord...
متن کاملMolecular basis of growth, proliferation, and differentiation of mammalian follicular granulosa cells.
For normal folliculogenesis and oogenesis to occur many intrinsic and extrinsic factors are needed, i.e. positive feedback of hormone secretion and local ovarian-follicular growth factors distribution. During follicle formation, granulosa cells (GCs) change their morphology and physiological properties. The factors needed for GCs to differentiate within each layer are transforming growth factor...
متن کاملThe Effects of Lithium Chloride on Survival and Function of in Vitro Cultured Human Granulosa Cells
Purpose: To investigate the effect of lithium chloride (LiCl) on survival and functional activity of in vitro cultured human granulosa cells (GCs). Materials and Methods: GCs were isolated from follicular fluid of women undergoing IVF/ICSI. After RBCs removal, GCs were plated in a medium containing varying concentrations of LiCl including 1, 2 and 5mM for two weeks period. A culture without Li...
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ژورنال
عنوان ژورنال: Journal of Reproduction and Development
سال: 2012
ISSN: 0916-8818,1348-4400
DOI: 10.1262/jrd.2011-012